Chemioterapia może doprowadzić do wyleczenia CLL

Ostatnio w BLOOD ukazał się interesujący artykuł autorstwa Thompson TA et al podsumowujący długoterminowe efekty leczenia CLL przy pomocy FCR. Bardzo interesujący jest brak progresji choroby u osób ze zmutowanym IGHV po 8-10 latach utrzymania remisji choroby – oznacza to szanse na całkowite wyleczeni CLL przy pomocy chemioterapii w tej grupie chorych.

Cały artykuł jest dostępny tutaj: link

Przechwytywanie

ASH 2015 – updates

The ASH 2015 is over. For those who could not attend MEDSCAPE has prepared very nice review of the new trial results that were presented on that conference.

http://www.medscape.org/viewarticle/849707?src=mkmcmr_driv_invit_mscpedu

For me the most important trial results were CAR-T cells used in Multiple Myeloma patients. The patients included in the study presented here had on average 7 lines of previous therapy and were refractory to treatment. The patients with maximal doses of CAR-T cells had striking responses:

” The second patient treated on the 9×106CAR+ T cells/kg dose level, Patient 11, had IgG lambda MM with 80% bone marrow plasma cells before treatment.  Patient 11 experienced signs of cytokine release syndrome with toxicities including fever, tachycardia, hypotension, delirium, hypoxia, and coagulopathy.  Patient 11’s M-protein decreased from 3.6 g/dL before treatment to 0.8 g/dL 4 weeks after treatment.  His serum lambda free light chain decreased from 95.9 mg/dL before treatment to 0.15 mg/dL 4 weeks after treatment.  Four weeks after CAR T-cell infusion, bone marrow plasma cells were undetectable. ” (Source ASH 2015 abstract 87396)

This is as amazing as it gets!